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Where indicated, a subset of subjects were instructed to continue with their current diet but, in addition, were placed on oral l-carnitine supplement (500 mg l-carnitine tartrate daily) and rechallenged in follow-up visits at 1 month and 23 months from baseline

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In accordance with previous studies 28,29 , we administered a ferroptosis inducer, erastin, to HT1080 cell culture and observed decrease in GSH levels by flow cytometry of RT signals (Fig

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